Drug surfactant interactions have received an increased attention in the recent past because of wide- spread applications of surfactants in pharmaceutical field. The physiochemical interaction of drugs with surfactant micelles can be visualized as an approximation for their interactions with biological tissues at the molecular level is their ability to bind to membrane resulting into drug action. This thesis investigates the physico-chemical properties to obtain the critical micelle concentration (CMC) and thermodynamic properties i.e the values of DeltaH°m, DeltaG°m, DeltaS°m of surfactants i.e an- ionic surfactant sodium dodecyl sulfate (SDS), cationic surfactant cetyl trim ethyl ammonium bro- mide (CTAB), non-ionic surfactant TWEEN 20 in presence of anti microbial drug i.e. itraconazole, at different temperatures 25ºc, 30ºc and 35ºc. Further topical gel formulations have been formed and its physical & analytical evaluation (physical appearance & spreadability) studies with the help of optimum concentration of drug/surfactants have been evaluated.
